https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=7593
No pharmaceutical opinion available for this interaction.
Lopinavir / ritonavir may induce the metabolism (UGT) and decrease the plasma concentration of Valproic acid (valproate, divalproex).
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–
–
Possible decrease of clinical efficacy.
Monitor for treatment response.
Adjust dosage if necessary.
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–
Valproic acid
Reference number |
---|
# patients |
HIV |
Dose |
Frequency |
AUC |
Duration (days) |
1623 |
---|
8 |
+ |
400/100 mg |
BID |
+ 38% * |
1623 |
---|
11 |
+ |
250 mg |
BID |
7 |
Ref #1623 : * Refers to lopinavir.
There were no significant differences in lopinavir Cmin (6.81 vs 10.7 ng/ml) or Cmax (12.4 vs 16.5 ng/ml) when given with valproic acid. Valproic acid trough not significantly
changed.
Ref #1940 : A case report of a 30 year old man with valproic acid concentrations decreased (- 48%) 21 days after starting lopinavir/ritonavir; valproic acid dosage was doubled and levels re-stabilized.