https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=6568
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=6568
No pharmaceutical opinion available for this interaction.
Phenobarbital can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Lopinavir / ritonavir.
Lopinavir / ritonavir can induce the metabolism (CYP 2C9 and CYP 2C19) and decrease the plasma concentration of Phenobarbital.
Possible decrease of clinical efficacy.
Risk of a possible development of resistance to antiretroviral class.
Monitor for signs and symptoms of therapeutic failure.
An increase in dosage may be necessary.
Lopinavir/ritonavir must not be administered once daily in combination with this drug.
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Possible decrease of clinical efficacy.
Avoid if possible. Use an alternative or monitor patient closely.
Monitor for signs and symptoms of therapeutic failure.
Titrate dose based on patient response and tolerability.
As clinically indicated : brivaracetam, gabapentin, lacosamide, lamotrigine, levetiracetam, pregabalin, rufinamide, topiramate, vigabatrin, zonisamide.
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Phenobarbital
Lopinavir plasma level
CD4+
Viral load HIV
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