Glecaprevir / Pibrentasvir

Phenytoin

Not recommended association.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Phenytoin may induce CYP 3A4 and P-gp and decrease the plasma concentration of Glecaprevir / Pibrentasvir.

Glecaprevir / Pibrentasvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Alternative solution(s)

Phenytoin

Pharmacodynamic effects

Recommendations

Avoid association.

Alternative solution(s)

Monitor

Tests

Pharmacokinetic parameters

Comment

See glecaprevir/pibrentasvir + carbamazepine.

Reference
  • 3373
    Glecaprevir/Pibrentasvir (Maviret), Abbvie, Québec, Canada, 28 novembre 2018.