Sofosbuvir / Velpatasvir / Voxilaprevir

Oxcarbazepine

Combination not recommended.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Oxcarbazepine may induce P-gp and CYP450 and decrease the plasma concentration of Sofosbuvir / Velpatasvir / Voxilaprevir.

Sofosbuvir / Velpatasvir / Voxilaprevir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Alternative solution(s)

Oxcarbazepine

Pharmacodynamic effects

Recommendations

Avoid association.

Alternative solution(s)

Gabapentin, pregabalin, levetiracetam, brivaracetam, or valproic acid

Monitor

Tests

Pharmacokinetic parameters

Comment

Reference
  • 3379
    Sofosbuvir/Velpatasvir/Voxilaprevir (VOSEVI), Gilead, Ontario, Canada, 28 janvier 2020.