https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19298
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19298
Document made available to the pharmacist to communicate a drug interaction to the doctor.
DOWNLOADSofosbuvir / Velpatasvir / Voxilaprevir may inhibit hepatic transports OATP1B1 and BCRP and increase plasma concentration of Rosuvastatin.
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Possible increased risk of HMG CoA inhibitor toxicity.
Increased risk of myopathy and rhabdomyolysis.
Contraindicated. Use alternative.
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| Reference number |
|---|
| # patients |
| Dose |
| HCV |
| Frequency |
| AUC |
| Cmax |
| 3379 |
|---|
| 19 |
| 400/100/200 mg |
| - |
| QD |
| 3379 |
|---|
| 19 |
| 10 mg |
| - |
| x 1 |
| + 639% (7.4x) |
| + 1788% (18.9x) |
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