Sofosbuvir / Velpatasvir / Voxilaprevir

Phenobarbital

Contraindicated.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Phenobarbital may induce P-gp and CYP450 and decrease the plasma concentration of Sofosbuvir / Velpatasvir / Voxilaprevir.

Sofosbuvir / Velpatasvir / Voxilaprevir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Alternative solution(s)

Phenobarbital

Pharmacodynamic effects

Recommendations

Contraindicated. Use alternative.

Alternative solution(s)

Monitor

Tests

Pharmacokinetic parameters

Comment

Reference
  • 3379
    Sofosbuvir/Velpatasvir/Voxilaprevir (VOSEVI), Gilead, Ontario, Canada, 18 avril 2018.