https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19294

Sofosbuvir / Velpatasvir / Voxilaprevir

Phenobarbital

Contraindicated.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

DOWNLOAD
Mechanism

Phenobarbital may induce P-gp and CYP450 and decrease the plasma concentration of Sofosbuvir / Velpatasvir / Voxilaprevir.

Sofosbuvir / Velpatasvir / Voxilaprevir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

–

Alternative solution(s)

–

Phenobarbital

Pharmacodynamic effects

–

Recommendations

Contraindicated. Use alternative.

Alternative solution(s)

Gabapentin, pregabalin, levetiracetam, brivaracetam, or valproic acid

Monitor

–

Tests

–

Pharmacokinetic parameters

–

Comment

–

Reference
  • 3379
    Sofosbuvir/Velpatasvir/Voxilaprevir (VOSEVI), Gilead, Ontario, Canada, 28 janvier 2020.