https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19263
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19263
Document made available to the pharmacist to communicate a drug interaction to the doctor.
DOWNLOADGlecaprevir / Pibrentasvir may inhibit CYP 3A4 and OATP1B1 and increase the plasma concentration of Simvastatin.
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Possible increased risk of HMG CoA inhibitor toxicity.
Increased risk of myopathy and rhabdomyolysis.
Avoid association. Choose an alternative.
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Symptoms of toxicity associated with hypolipidemic agents : gastrointestinal effects, fatigue and muscular weaknesses, myalgias, muscular cramps, myopathies, rhabdomyolysis and myoglobinuria leading to renal insufficiency.
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| Reference number |
|---|
| # patients |
| HCV |
| Dose |
| Frequency |
| Cmax |
| AUC |
| 3373 |
|---|
| 12 |
| - |
| 300/120 mg |
| QD |
| 3373 |
|---|
| 12 |
| - |
| 5 mg |
| QD |
| + 99% (2x) * |
| + 132% (2.3x) * |
Ref #3373 : * Simvastatin acid (metabolite) AUC +348% (4.5x) and Cmax +970% (10.7x).