https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19251

Glecaprevir / Pibrentasvir

St. John's Wort

Combination not recommended.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

St. John's Wort may induce CYP 3A4 and P-gp and decrease the plasma concentration of Glecaprevir / Pibrentasvir.

Glecaprevir / Pibrentasvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

–

Alternative solution(s)

–

St. John's Wort

Pharmacodynamic effects

–

Recommendations

Avoid association.

Alternative solution(s)

–

Monitor

–

Tests

–

Pharmacokinetic parameters

–

Comment

–

Comment
Reference
  • 3373
    Glecaprevir/Pibrentasvir (Maviret), Abbvie, Québec, Canada, 30 octobre 2020.