https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19211
No pharmaceutical opinion available for this interaction.
Bictegravir can inhibit the renal transport (OCT2 and MATE 1) and increase plasma concentration of Metformin.
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Interaction considered clinically non-significant according to the monograph.
No dosage adjustment is necessary.
Close monitoring of adverse effects should be considered in patients with moderate renal impairment.
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Adverse effects of metformin: gastrointestinal effects and symptoms related to hypoglycemia.
Monitor signs and symptoms of lactic acidosis: nausea, vomiting, stomach pain, weight loss, shortness of breath, and great fatigue.
Blood Sugar
Reference number |
---|
# patients |
Dose |
Frequency |
Duration (days) |
HIV |
AUC |
Cmax |
Cmin |
3368 |
---|
16 |
75 mg * |
QD |
4 |
- |
3368 |
---|
16 |
850 mg/500 mg † |
BID † |
4 |
- |
+ 39% ° |
+ 28% ° |
+ 36% ° |
Ref #3368 : * Given with emtricitabine/tenofovir alafenamide (200/25 mg).
† 850 mg metformin at 12 hours postdose of B/F/TAF or placebo and 500 mg BID after.
° When coadministered with B/F/TAF relative to placebo.
Metformin t1/2 was similar, renal clearance decreased approximately by 31% but importantly, clinically-relevant pharmacodynamics responses were not statistically different.