https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=16246
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=16246
Document made available to the pharmacist to communicate a drug interaction to the doctor.
DOWNLOADSofosbuvir / Velpatasvir can decrease the P-gp and increase the plasma concentration of Digoxin.
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Possible increase of adverse effects.
Use this combination with caution.
Monitor for development of adverse effects and adjust dosage if necessary.
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Adverse effects of digoxin: Gastrointestinal effects (abdominal discomfort, nausea/vomiting, diarrhea, anorexia, dyspepsia), central nervous system effects, vision disorders, fatigue, headache, bradycardia and rhythm disorders.
ECG
Digoxinemia
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Ref # 3250: In 21 healthy subjects, concomitant administration of a single dose of digoxin 0.25 mg with velpatasvir 100 mg QD increased digoxin AUC and Cmax by 34% and 88%, respectively.