https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=16240
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=16240
Document made available to the pharmacist to communicate a drug interaction to the doctor.
DOWNLOADOmeprazole by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of velpatasvir .
Possible decrease of clinical efficacy.
Monitor for clinical efficacy.
–
–
Proton-pump inhibitor can be administered simultaneously with ledipasvir/sofosbuvir when it is taken with food.
PPI doses should not exceed comparable to omeprazole 20 mg QD either dexlansoprazole 30 mg; esomeprazole 20 mg; lansoprazole 30 mg; pantoprazole 40 mg; rabeprazole 20 mg.
–
–
–
| Reference number |
|---|
| # patients |
| HCV |
| Dose |
| Frequency |
| AUC |
| Cmax |
| 3250 | 3250 | 3250 | 3250 | 3250 |
|---|---|---|---|---|
| 60 | 40 | 38 | 40 | 60 |
| - | - | - | - | - |
| 400/100 mg | 400/100 mg | 400/100 mg | 400/100 mg | 400/100 mg |
| x 1 ° | x 1 °° | x 1 °° | x 1 °° | x 1 ° |
| - 29%/- 36% † | + 8%/- 38% †† | + 5%/- 26% ††† | - 9%/- 53% †††† | - 44%/- 55% ††††† |
| - 34%/- 37% † | - 16%/- 48% †† | - 21%/- 33% ††† | - 30%/- 56% †††† | - 45%/- 57% ††††† |
| 3250 | 3250 | 3250 | 3250 | 3250 |
|---|---|---|---|---|
| 60 | 40 | 38 | 40 | 60 |
| - | - | - | - | - |
| 20 mg | 20 mg | 20 mg | 40 mg | 20 mg |
| QD * | QD ** | QD *** | QD *** | QD **** |
Ref #3250 :
° Administred in fasting state;
°° Sofosbuvir/velpatasvir adminsitered with food;
* Omeprazole administered at the same time as sofosbuvir/velpatasvir;
** Omeprazole administered 2 hours before sofosbuvir/velpatasvir;
*** Oméprazole administré 4 hours after sofosbuvir/velpatasvir;
**** Omeprazole administered 12 hours before sofosbuvir/velpatasvir;
† GS-331007 : AUC -1% and Cmax -6%;
†† GS-331007 : AUC -1% and Cmax -9%;
††† GS-331007 : AUC -1% and Cmax -9%;
†††† GS-331007 : AUC -1% and Cmax +1%
††††† GS-331007 : SSC -3% and Cmax +26%.