https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=16234

Sofosbuvir / Velpatasvir

Magnesium (hydroxide)

A spacing between the drugs is required.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

DOWNLOAD
Mechanism

Magnesium (hydroxide) by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of velpatasvir .

Sofosbuvir / Velpatasvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Administer at least 4 hours before or after the antacid.

Monitor for clinical efficacy.

Alternative solution(s)

–

Magnesium (hydroxide)

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Monitor

–

Tests

–

Pharmacokinetic parameters

–

Comment

–

Comment
Reference
  • 3250
    Sofosbuvir/Velpatasvir (Epclusa), Gilead Sciences, Ontario, Canada, 5 novembre 2020.