https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=13500

Ledipasvir / Sofosbuvir

Rabeprazole

Administration time adjustment is recommended.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Rabeprazole by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of ledipasvir .

Ledipasvir / Sofosbuvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy.

Alternative solution(s)

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Rabeprazole

Pharmacodynamic effects

–

Recommendations

Give ledipasvir/sofosbuvir simultaneously with the proton-pump inhibitor.

Recommended dosage : doses comparable to omeprazole 20 mg QD either dexlansoprazole 30 mg; esomeprazole 20 mg; lansoprazole 30 mg; pantoprazole 40 mg; rabeprazole 20 mg.

Alternative solution(s)

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Monitor

–

Tests

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Pharmacokinetic parameters

–

Comment

See lepidasvir/sofosbuvir + omeprazole.

Comment
Reference
  • 3073
    Ledipasvir/Sofosbuvir (Harvoni), Gilead, Ontario, Canada, 16 avril 2018.