https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=13496
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=13496
Document made available to the pharmacist to communicate a drug interaction to the doctor.
DOWNLOADOmeprazole by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of ledipasvir .
Possible decrease of clinical efficacy.
Monitor for clinical efficacy.
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Give ledipasvir/sofosbuvir simultaneously with the proton-pump inhibitor.
Recommended dosage : doses comparable to omeprazole 20 mg QD either dexlansoprazole 30 mg; esomeprazole 20 mg; lansoprazole 30 mg; pantoprazole 40 mg; rabeprazole 20 mg.
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| Reference number |
|---|
| # patients |
| HIV/HCV |
| Dose |
| Frequency |
| Cmax |
| AUC |
| 3073 |
|---|
| 16 |
| - |
| 90 / 400 mg |
| QD |
| - 11% / + 12% † |
| - 4% / ± 0% † |
| 3073 |
|---|
| 16 |
| - |
| 20 mg |
| x 1 * |
Ref #3073 :
* Omeprazole and Oméprazole et ledipasvir/sofosbuvir taken at the same time.
† GS-331007, sofosbuvir active metabolite : AUC +3% and Cmax +14%.
In another study with ledipasvir alone, there was a 48% and 42% decrease in Cmax and AUC when ledipasvir was given 2 hours after omeprazole 20 mg.
Equivalent doses to omeprazole 20 mg: dexlansoprazole 30 mg; esomeprazole 20 mg; lansoprazole 30 mg; pantoprazole 40 mg; rabeprazole 20 mg.