No pharmaceutical opinion available for this interaction.
Carbamazepine can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Darunavir / cobicistat.
Darunavir / cobicistat may possibly inhibit the metabolism (CYP 3A4) and consequently increase the plasma concentration of Carbamazepine.
3A4 (major) and 2D6 (minor)
3A4 (potent) and 2D6 (weak), P-gp, MATE 1, BCRP, OATP1B1 and OATP1B3.
Possible decrease of clinical efficacy.
Risk of a possible development of resistance to antiretroviral class.
Monitor for signs and symptoms of therapeutic failure.
3A4 (main), 2C8, 1A2; Active metabolite: epoxide hydrolase (CBZ-10,11- epoxide)
3A4 (potent), 2C9, 2C19, P-gp, UGT and possibly 1A2
Possible increase of adverse effects.
Contraindicated. Use alternative.
Gabapentin, pregabaline, leviracetam.
Carbamazepine adverse effects : disorientation, ataxia, lethargy, drowsiness, nausea, vomiting, headache, diplopia, dizziness, leukopenia and hyponatremia.
Darunavir plasma level
Viral load HIV
See carbamazepine + elvitegravir/cobicistat.
Ref #1304 : Reported case of a 20-year-old patient who developed vomiting, dizziness, elevated liver enzymes, and increased carbamazepine concentration by 87% following the addition of one dose of ritonavir 200 mg. Symptoms started within 12 hours after the first dose of ritonavir. In order to obtain a concentration within the therapeutic index, the dose of carbamazepine was reduced from 750 to 280 mg QD. Several other cases of acute toxicity to carbamazepine 2 to 4 days after the addition of ritonavir have been reported. See ritonavir + carbamazepine.
Ref #2090: Another case reported of a 50 year man who developed excessive drowsiness following the introduction of lopinavir/ritonavir and it was found that his serum carbamazepine concentration had increased by 46%. His antiretroviral therapy was then changed to nelfinavir 1250 mg BID but 3 days later the same symptoms appeared with 53% increase in carbamazepine. The symptoms of carbamazepine toxicity disappeared after a carbamazepine dose reduction of 33%. See lopinavir/ritonavir + carbamazepine.