https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=11321
No pharmaceutical opinion available for this interaction.
Aluminium / Magnesium hydroxide can bind (chelation) to elvitegravir and reduce its absorption .
Possible decrease of clinical efficacy.
The product monograph recommends to separate administration of elvitegravir and antacids by at least 2 hours.
Monitor for clinical efficacy.
–
–
–
H2 receptor antagonists or proton pump inhibitors.
–
Viral Load
CD4+
Reference number |
---|
# patients |
HIV |
Dose |
Frequency |
AUC |
Cmax |
Cmin |
2134 | 2134 | 2134 | 2134 | 2134 |
---|---|---|---|---|
13 | 11 | 10 | 8 | 10 |
- | - | - | - | - |
50 mg * | 50 mg * | 50 mg * | 50 mg * | 50 mg * |
x 1 † | x 1 ‡ | x 1 ‡‡ | x 1 ° | x 1 °° |
- 45% | - 15% | - 20% | - 4% | - 2% |
- 47% | - 18% | - 21% | - 5% | - 2% |
- 41% | - 10% | - 20% | + 4% | ± 0% |
2134 | 2134 | 2134 | 2134 | 2134 |
---|---|---|---|---|
13 | 11 | 10 | 8 | 10 |
- | - | - | - | - |
20 ml | 20 ml | 20 ml | 20 ml | 20 ml |
x 1 † | x 1 ‡ | x 1 ‡‡ | x 1 ° | x 1 °° |
Ref #2134 : * Elvitegravir administered with ritonavir 100 mg.
† Elvitegravir administered simultaneously with the antacid.
‡ Antacid administered 2 before elvitegravir.
‡‡ Antacid administered 2 hours after elvitegravir.
° Antacid administered 4 hours before elvitegravir.
°° Antacid administered 4 hours after elvitegravir.
Also see Elvitegravir/Ritonavir + antacids.
Also see Famotidine with Elvitegravir\cobicistat and Omeprazole with Elvitegravir/cobicistat.