https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=11108

Dolutegravir

Glycopyrronium

Potential interaction.

No pharmaceutical opinion available for this interaction.

Mechanism

Dolutegravir may inhibit MATE 1 and increase the plasma concentration of Glycopyrronium.

Dolutegravir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Glycopyrronium

Pharmacodynamic effects

Possible increase of adverse effects.

Clinical significance unknown.

Recommendations

Monitor for adverse effects.

Alternative solution(s)

–

Monitor

Anticholinergic adverse effects: xerostomia, constipation, urinary retention, sedation, drowsiness, blurred vision, akathisia, convulsions, tachycardia, hypotension, etc.

Tests

–

Pharmacokinetic parameters

–

Comment

–

Reference
  • 3213
    Glycopyrronium (Seebri Breezhaler), Novartis Pharma, Québec, Canada, 21 janvier 2016.