Paramètres pharmacocinétiques

Commentaire

Association généralement bien tolérée, il est cependant préférable de commencer la pravastatine à faible dose car il y a une grande variabilité interindividuelle.

Réf #2380 : La co-administration la pravastatine avec le darunavir/ritonavir a augmenté la SSC de la pravastatine de 21%.

Réf #2129 : Cependant, dans une autre étude avec darunavir/ritonavir, on a observé une augmentation moyenne de la SSC de la pravastatine de 81% avec des augmentations allant jusqu'à 5 fois chez quelques sujets.

Réf #3391 : Rapport de cas de rhabdomyolyse chez un patient sous élvitegravir/cobicistat et pravastatine/fénofibrate.

Reférences

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  Carr RA, Andre AK, Bertz RJ et al. Concomitant administration of ABT-378/ritonavir (ABT-378/r) results in a clinically important pharmacokinetic (PK) interaction with atorvastatin (ATO) but not pravastatin (PRA). 40th ICAAC. Toronto, Canada, September 17-20, 2000 Abstract 1644.
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  Pravastatin (Pravachol), Bristol-Myers Squibb Canada, Québec, Canada, 18 octobre 2017.
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  Jacobson TA. Comparative Pharmacokinetic Interaction Profiles of Pravastatin, Simvastatin and Atorvastatin When Coadministered Whit Cytochrome P450 Inhibitors. Am J Cardiol 2004; 94 : 1140-1146.
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  Moyle GJ, Buss NE, and Gazzard B. Pravastatin 40-mg qd Does not Alter Protease Inhibitor (PI) Exposure or Virological Efficacy over 24 Weeks Therapy. 9th Conference on Retroviruses and Opportunistic Infections. Seattle, Washington. February 2002. Abstract 446-W
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  Sekar VJ, Spinosa-Guzman S, Marien K, et al. Interaction between the new HIV protease inhibitor darunavir (TMC114) and the lipid-lowering agent pravastatin. 8th International Workshop on Clinical Pharmacology of HIV Therapy, 16-18 April 2007, Budapest, Hungary. Abstract 54.
• 2380
  Aquilante, C. Kiser, J. Anderson, P. et al. DRV/R, pravastatin and pharmacogenetics: Influence of SL01B1 polymorphisms on pharmacokinetic variability in the drug-drug interaction between darunavir/ritonavir and pravastatin. Drug Interaction & Pharmacology Presentations at the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy, Boston, September 2010. Abstract A1 2007
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  Suttels V, Florence E, Leys J, et al. A 68-year old male presenting with rhabdomyolysis-associated acute kidney injury following concomitant use of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate and pravastatin/fenofibrate: a case report. J Med Case Rep, 2015, 9: 190.