https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=9814

Darunavir / ritonavir

Codeine

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Darunavir / ritonavir may inhibit the metabolism (CYP2D6) and decrease the conversion into morphine, active metabolite of Codeine.

Darunavir / ritonavir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Codeine

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy.

Dosage adjustment may be required.

Alternative solution(s)

Hydromorphone or morphine.

Monitor

Signs and symptoms of opioid withdrawal : craving for opioids, irritability, myalgias, muscle spasms, flushing, abdominal pain, nausea, vomiting, diarrhea, restlessness, diaphoresis, lacrimation, rhinorrhea, mydriasis, yawning, piloerection (goose flesh), tachycardia, tremulousness.

Tests

–

Pharmacokinetic parameters

–

Comment

–

Reference
  • 2572
    Ritonavir (Norvir), Corporation AbbVie, Quebec, Canada, 5 juillet 2021.
  • 2616
    Susce MT, Murray-Carmichael E, de Leon J. Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer. Prog Neuropsychopharmacol Biol Psychiatry. 2006. September 30; 30(7): 1356-1358.