No pharmaceutical opinion available for this interaction.
Darunavir / ritonavir may inhibit the metabolism (CYP2D6) and decrease the conversion into morphine, active metabolite of Codeine.
2C9, 2C19, 2C8 (moderate), UGT (moderate)
3A4 (strong), 2D6 (moderate), 2B6 (probable)
2D6 (major) - morphine (10%); 3A4 (minor) - norcodeine (10-15%); UGT2B7 - codeine-6 glucuronide (active metabolite) (50-70%).
Possible decrease of clinical efficacy.
Monitor for clinical efficacy.
Dosage adjustment may be required.
Hydromorphone or morphine.
Signs and symptoms of opioid withdrawal : craving for opioids, irritability, myalgias, muscle spasms, flushing, abdominal pain, nausea, vomiting, diarrhea, restlessness, diaphoresis, lacrimation, rhinorrhea, mydriasis, yawning, piloerection (goose flesh), tachycardia, tremulousness.