https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=9814
No pharmaceutical opinion available for this interaction.
Darunavir / ritonavir may inhibit the metabolism (CYP2D6) and decrease the conversion into morphine, active metabolite of Codeine.
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Possible decrease of clinical efficacy.
Monitor for clinical efficacy.
Dosage adjustment may be required.
Hydromorphone or morphine.
Signs and symptoms of opioid withdrawal : craving for opioids, irritability, myalgias, muscle spasms, flushing, abdominal pain, nausea, vomiting, diarrhea, restlessness, diaphoresis, lacrimation, rhinorrhea, mydriasis, yawning, piloerection (goose flesh), tachycardia, tremulousness.
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