https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=9814

Darunavir / ritonavir

Codeine

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Darunavir / ritonavir may inhibit the metabolism (CYP2D6) and decrease the conversion into morphine, active metabolite of Codeine.

Darunavir / ritonavir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Codeine

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy.

Dosage adjustment may be required.

Alternative solution(s)

Depending on the clinical indication, acetaminophen, NSAIDs when possible, hydromorphone or morphine.

Monitor

Signs and symptoms of opioid withdrawal : craving for opioids, irritability, myalgias, muscle spasms, flushing, abdominal pain, nausea, vomiting, diarrhea, restlessness, diaphoresis, lacrimation, rhinorrhea, mydriasis, yawning, piloerection (goose flesh), tachycardia, tremulousness.

Tests

–

Pharmacokinetic parameters

–

Comment

–

Comment
Reference
  • 2572
    Ritonavir (Norvir), Corporation AbbVie, Quebec, Canada, 5 juillet 2021.
  • 2616
    Susce MT, Murray-Carmichael E, de Leon J. Response to hydrocodone, codeine and oxycodone in a CYP2D6 poor metabolizer. Prog Neuropsychopharmacol Biol Psychiatry. 2006. September 30; 30(7): 1356-1358.