https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=9784

Elvitegravir / Cobicistat

Oxcarbazepine

Not recommended association.

No pharmaceutical opinion available for this interaction.

Mechanism

Oxcarbazepine can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Elvitegravir / Cobicistat.

Elvitegravir / Cobicistat

Pharmacodynamic effects

Decreased clinical efficacy.

Risk of a possible development of resistance to antiretroviral class.

Recommendations

Monitor for signs and symptoms of therapeutic failure.

Alternative solution(s)

–

Oxcarbazepine

Pharmacodynamic effects

–

Recommendations

Avoid association. Choose an alternative.

Alternative solution(s)

Selon l’indication clinique : brivaracétam, gabapentine, lacosamide, lamotrigine, lévétiracétam, prégabaline, rufinamide, topiramate, vigabatrine, zonisamide.

Monitor

–

Tests

Viral Load

CD4+

Elvitegravir plasma level

Pharmacokinetic parameters

–

Comment

–

Reference
  • 2570
    Elvitegravir/cobicistat/emtricitabine/tenofovir (Stribild), Gilead, Ontario, Canada, 17 septembre 2018.
  • 3141
    Oxcarbazepine (Trileptal), Novartis, Québec, Canada, 18 mars 2015.
  • 3281
    Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (Genvoya), Gilead, Ontario, Canada, 6 août 2021.