https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=8428
No pharmaceutical opinion available for this interaction.
Darunavir / ritonavir can induce the metabolism (UGT 1A4) and decrease the concentration of Lamotrigine.
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Possible decrease of clinical efficacy.
An increase in dosage may be necessary.
Monitor for signs and symptoms of therapeutic failure.
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Lamotrigine
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Pharmacokinetic studies showed that the addition of a protease inhibitor (PI) combination containing ritonavir decreases lamotrigine plasma concentrations of about 32 to 55%. A lamotrigine dose of 200 mg BID with PI produces a concentration similar to lamotrigine 100 mg BID used alone.
See atazanavir/ritonavir + lamotrigine and lopinavir/ritonavir + lamotrigine.