https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=8270
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=8270
No pharmaceutical opinion available for this interaction.
Oxcarbazepine can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Atazanavir / ritonavir.
Possible decrease of clinical efficacy.
Monitor for signs and symptoms of therapeutic failure.
Should not be administered without low-dose ritonavir or cobicistat.
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Avoid association. Choose an alternative.
As clinically indicated : brivaracetam, gabapentin, lacosamide, lamotrigine, levetiracetam, pregabalin, rufinamide, topiramate, vigabatrin, zonisamide.
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Atazanavir plasma level
CD4+
Viral load HIV
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Ref #3570: TDM data were evaluated 11 HIV-positive patients treated concomitantly with carbamazepine or oxcarbazepine and antiretrovirals for at least 3 months. All the TDM evaluations for carbamazepine and oxcarbazepine were within therapeutic ranges. Conversely, trough concentrations for atazanavir demonstrated significantly lower values (- 65%) when compared with values usually measured in HIV-infected patients not treated with antiepileptic drugs.