Lopinavir / ritonavir

Lamotrigine

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Lopinavir / ritonavir can induce the metabolism (UGT 1A4) and decrease the concentration of Lamotrigine.

Lopinavir / ritonavir

Pharmacodynamic effects

Recommendations

Alternative solution(s)

Lamotrigine

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

An increase in dosage may be necessary.

Monitor for signs and symptoms of therapeutic failure.

Alternative solution(s)

Monitor

Tests

Lamotrigine

Pharmacokinetic parameters
Parameters
Reference number
HIV
PK parameters
# patients
Duration (days)
Dose
Frequency
Cmin
Lopinavir / ritonavir
2111
-
+/- 0% *
18
10
400/100 mg
BID
 
Lamotrigine
2111
-
 
18
21
100 mg
BID
- 55%
Comment

* Compared to historical controls.

Ref #2111: An increase in the dose of lamotrigine from 100 mg BID to 200 mg BID produce a concentration similar to lamotrigine 100 mg BID used alone.

Reference
  • 2111
    Van der Lee MJ, Dawood L, ter Hofstede H, et al. Lopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy subjects. Clin Pharmacol Ther 2006; 80:159-168.
  • 2377
    Lopinavir/ritonavir (Kaletra). Coorporation Abbvie, Quebec, Canada, 5 oct 2017.