https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=8219

Lopinavir / ritonavir

Lamotrigine

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Lopinavir / ritonavir can induce the metabolism (UGT 1A4) and decrease the concentration of Lamotrigine.

Lopinavir / ritonavir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Lamotrigine

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

An increase in dosage may be necessary.

Monitor for signs and symptoms of therapeutic failure.

Alternative solution(s)

–

Monitor

–

Tests

Lamotrigine

Pharmacokinetic parameters
Parameters
Reference number
HIV
PK parameters
# patients
Duration (days)
Dose
Frequency
Cmin
Lopinavir / ritonavir
2111
-
+/- 0% *
18
10
400/100 mg
BID
 
Lamotrigine
2111
-
 
18
21
100 mg
BID
- 55%
Comment

* Compared to historical controls.

Ref #2111: An increase in the dose of lamotrigine from 100 mg BID to 200 mg BID produce a concentration similar to lamotrigine 100 mg BID used alone.

Comment
Reference
  • 2111
    Van der Lee MJ, Dawood L, ter Hofstede H, et al. Lopinavir/ritonavir reduces lamotrigine plasma concentrations in healthy subjects. Clin Pharmacol Ther 2006; 80:159-168.
  • 2377
    Lopinavir/ritonavir (Kaletra). Coorporation Abbvie, Quebec, Canada, 5 oct 2017.