https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=8219
No pharmaceutical opinion available for this interaction.
Lopinavir / ritonavir can induce the metabolism (UGT 1A4) and decrease the concentration of Lamotrigine.
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–
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Possible decrease of clinical efficacy.
An increase in dosage may be necessary.
Monitor for signs and symptoms of therapeutic failure.
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Lamotrigine
Reference number |
---|
HIV |
PK parameters |
# patients |
Duration (days) |
Dose |
Frequency |
Cmin |
2111 |
---|
- |
+/- 0% * |
18 |
10 |
400/100 mg |
BID |
2111 |
---|
- |
18 |
21 |
100 mg |
BID |
- 55% |
* Compared to historical controls.
Ref #2111: An increase in the dose of lamotrigine from 100 mg BID to 200 mg BID produce a concentration similar to lamotrigine 100 mg BID used alone.