No pharmaceutical opinion available for this interaction.
Lopinavir / ritonavir can induce the metabolism (UGT 1A4) and decrease the concentration of Lamotrigine.
3A4 (major), 13 identified metabolites, 5 of these metabolites are linked to the metabolism of ritonavir, transporters: MRP1, MRP2, OATP1A2, OATP1B1, P-gp
2C19 (strong), 1A2, 2C9 (moderate) UGT (moderate)
3A4 and 2D6 (strong), transporters: BCRP, MRP2, OATP1A2, OATP1B1, OATP1B3, OATP2B1, P-gp
UGT1A4 (65%), P-gp
UGT1A4 (light auto-induction)
Possible decrease of clinical efficacy.
An increase in dosage may be necessary.
Monitor for signs and symptoms of therapeutic failure.
|+/- 0% *|
* Compared to historical controls.
Ref #2111: An increase in the dose of lamotrigine from 100 mg BID to 200 mg BID produce a concentration similar to lamotrigine 100 mg BID used alone.