Darunavir / ritonavir

Valproic acid (valproate, divalproex)

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Darunavir / ritonavir may increase the metabolism (UGT) and decrease the plasma concentration of Valproic acid (valproate, divalproex).

Darunavir / ritonavir

Pharmacodynamic effects

Recommendations

Alternative solution(s)

Valproic acid (valproate, divalproex)

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for treatment response.

Adjust dosage if necessary.

Alternative solution(s)

Monitor

Tests

Valproic acid

Pharmacokinetic parameters

Comment

See valproic acid and lopinavir/ritonavir.

Reference
  • 1623
    DiCenzo R, Peterson D, Cruttenden K, et al. Effects of Valproic Acid Coadministration on Plasma Efavirenz and Lopinavir Concentrations in Human Immunodeficiency Virus-Infected Adults. Antimicrob Agents Chemother. 2004 November;48(11):4328–4331.
  • 1940
    Sheehan NL, Brouillette MJ, Delisle MS, and Allan J. Possible interaction between lopinavir/ritonavir and valproic acid exacerbates bipolar disorder. Ann Pharmacother 2006; 40(1):147-150.
  • 2968
    Ritonavir (Norvir), European public assessment report (EPAR) Product Information, London, United Kingdom, 18 fév 2014.