https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=8190

Darunavir / ritonavir

Valproic acid (valproate, divalproex)

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Darunavir / ritonavir may induce the metabolism (UGT) and decrease the plasma concentration of Valproic acid (valproate, divalproex).

Darunavir / ritonavir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Valproic acid (valproate, divalproex)

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for treatment response.

Adjust dosage if necessary.

Alternative solution(s)

–

Monitor

–

Tests

Valproic acid

Pharmacokinetic parameters

–

Comment

See valproic acid and lopinavir/ritonavir.

Comment
Reference
  • 2573
    Ritonavir (Norvir), Corporation AbbVie, Quebec, Canada, 5 juillet 2021.
  • 1623
    DiCenzo R, Peterson D, Cruttenden K, et al. Effects of Valproic Acid Coadministration on Plasma Efavirenz and Lopinavir Concentrations in Human Immunodeficiency Virus-Infected Adults. Antimicrob Agents Chemother. 2004 November;48(11):4328–4331.
  • 1940
    Sheehan NL, Brouillette MJ, Delisle MS, and Allan J. Possible interaction between lopinavir/ritonavir and valproic acid exacerbates bipolar disorder. Ann Pharmacother 2006; 40(1):147-150.
  • 2968
    Ritonavir (Norvir), European public assessment report (EPAR) Product Information, London, United Kingdom, 18 fév 2014.