https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=8112

Darunavir / ritonavir

Clobazam

Monitor more closely.

No pharmaceutical opinion available for this interaction.

Mechanism

Darunavir / ritonavir can inhibit the metabolism (CYP 3A4) and increase the plasma concentration of Clobazam.

Darunavir / ritonavir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Clobazam

Pharmacodynamic effects

Possible increase of adverse effects.

Recommendations

Monitor closely for side effects.

A reduction in dosage may be necessary.

Alternative solution(s)

Gabapentin, pregabaline, leviracetam.

Monitor

Benzodiazepine toxicity: drowsiness, dizziness, ataxia, problem of coordination, confusion, decrease of reflexes, excessive sedation, respiratory depression and coma.

Tests

–

Pharmacokinetic parameters

–

Comment

–

Comment
Reference
  • 3309
    Clobazam (Teva-Clobazam), Teva, Ontario, Canada, 20 oct. 2017.