No pharmaceutical opinion available for this interaction.
Darunavir / ritonavir can inhibit the metabolism (CYP 3A4) and increase the plasma concentration of Clobazam.
2C9, 2C19, 2C8 (moderate), UGT (moderate)
3A4 (strong), 2D6 (moderate), 2B6 (probable)
3A4 (major), 2C19 and 2B6 (to a lesser extent), P-gp; N-desmethylclobazam widely metabolized by 2C19
Possible increase of adverse effects.
Monitor closely for side effects.
A reduction in dosage may be necessary.
Gabapentin, pregabaline, leviracetam.
Benzodiazepine toxicity: drowsiness, dizziness, ataxia, problem of coordination, confusion, decrease of reflexes, excessive sedation, respiratory depression and coma.