No pharmaceutical opinion available for this interaction.
Oxcarbazepine can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Lopinavir / ritonavir.
3A4 (major), 13 identified metabolites, 5 of these metabolites are linked to the metabolism of ritonavir, transporters: MRP1, MRP2, OATP1A2, OATP1B1, P-gp
2C19 (strong), 1A2, 2C9 (moderate) UGT (moderate)
3A4 and 2D6 (strong), transporters: BCRP, MRP2, OATP1A2, OATP1B1, OATP1B3, OATP2B1, P-gp
Possible decrease of clinical efficacy.
An increase in dosage may be necessary.
Monitor for signs and symptoms of therapeutic failure.
Cytosolic system, UGT
3A4, P-gp, UGT
2C19 (mostly if > 1200 mg/d)
Avoid association. Choose an alternative.
Gabapentin, pregabalin, leviracetam.
Lopinavir plasma level
Viral load HIV