https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=8106

Lopinavir / ritonavir

Oxcarbazepine

Not recommended association.

No pharmaceutical opinion available for this interaction.

Mechanism

Oxcarbazepine can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Lopinavir / ritonavir.

Lopinavir / ritonavir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

An increase in dosage may be necessary.

Monitor for signs and symptoms of therapeutic failure.

For lopinavir/ritonavir, BID dosage is recommended. Avoid QD dosage.

Alternative solution(s)

–

Oxcarbazepine

Pharmacodynamic effects

–

Recommendations

Avoid association. Choose an alternative.

Alternative solution(s)

As clinically indicated : brivaracetam, gabapentin, lacosamide, lamotrigine, levetiracetam, pregabalin, rufinamide, topiramate, vigabatrin, zonisamide.

Monitor

–

Tests

Lopinavir plasma level

Viral load HIV

CD4+

Pharmacokinetic parameters

–

Comment

–

Reference
  • 3141
    Oxcarbazepine (Trileptal), Novartis, Québec, Canada, 18 mars 2015.
  • 2377
    Lopinavir/ritonavir (Kaletra). Coorporation Abbvie, Quebec, Canada, 5 oct 2017.