Lopinavir / ritonavir

Oxcarbazepine

Not recommended association.

No pharmaceutical opinion available for this interaction.

Mechanism

Oxcarbazepine can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Lopinavir / ritonavir.

Lopinavir / ritonavir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

An increase in dosage may be necessary.

Monitor for signs and symptoms of therapeutic failure.

Alternative solution(s)

Oxcarbazepine

Pharmacodynamic effects

Recommendations

Avoid association. Choose an alternative.

Alternative solution(s)

Gabapentin, pregabalin, leviracetam.

Monitor

Tests

Lopinavir plasma level

Viral load HIV

CD4+

Pharmacokinetic parameters

Comment

Reference
  • 3141
    Oxcarbazepine (Trileptal), Novartis, Québec, Canada, 18 mars 2015.
  • 2377
    Lopinavir/ritonavir (Kaletra). Coorporation Abbvie, Quebec, Canada, 5 oct 2017.