Ritonavir

Oxcarbazepine

Not recommended association.

No pharmaceutical opinion available for this interaction.

Mechanism

Oxcarbazepine can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Ritonavir.

Ritonavir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for signs and symptoms of therapeutic failure.

Alternative solution(s)

Oxcarbazepine

Pharmacodynamic effects

Recommendations

Avoid association. Choose an alternative.

Alternative solution(s)

Gabapentin, pregabalin, leviracetam.

Monitor

Tests

Associated PI plasma level

CD4+

Viral load HIV

Pharmacokinetic parameters

Comment

Reference
  • 122
    Ritonavir (Norvir), Corporation AbbVie, Quebec, Canada, 25 septembre 2018.
  • 3141
    Oxcarbazepine (Trileptal), Novartis, Québec, Canada, 18 mars 2015.