No pharmaceutical opinion available for this interaction.
Oxcarbazepine can induce the metabolism (CYP 3A4) and decrease the plasma concentration of Ritonavir.
3A4 and 2D6 (major), 1A2 and 2B6 (minor), 5 metabolites, one of which has a weak concentration of an active metabolite (M-2), transporters: MRP1, MRP2, P-gp
2B6, 2C8, 2C9, 1A2, 2C19 (moderate) UGT (moderate)
3A4 (potent) and 2D6 (moderate), transporters: BCRP, OATP1A2, OATP1B1, OATP1B3, MRP1, MRP2, OCT1, OCT2, P-gp
Possible decrease of clinical efficacy.
Monitor for signs and symptoms of therapeutic failure.
Cytosolic system, UGT
3A4, P-gp, UGT
2C19 (mostly if > 1200 mg/d)
Avoid association. Choose an alternative.
Gabapentin, pregabalin, leviracetam.
Associated PI plasma level
Viral load HIV