https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=7124
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=7124
No pharmaceutical opinion available for this interaction.
Lopinavir / ritonavir may possibly inhibit the metabolism (CYP 3A4) and consequently increase the plasma concentration of Buspirone.
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Possible increase of adverse effects.
Risk of prolonged sedation and respiratory depression.
Use with caution the lowest effective dose and adjust according to clinical response and tolerance.
Monitor closely for adverse effects.
Or choose an alternative.
In patients already being treated with this combination and tolerating it, if deemed appropriate, keep actual treatment and exercise close monitoring of adverse effects and clinical effectiveness.
Lorazepam (Ativan), temazepam (Restoril), oxazepam (Serax)
Buspirone toxicity: impaired psychomotor performance, nausea, vomiting, dizziness, drowsiness, miosis, etc.
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