https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=6891

Ritonavir

Clobazam

Monitor more closely.

No pharmaceutical opinion available for this interaction.

Mechanism

Ritonavir can inhibit the metabolism (CYP 3A4) and increase the plasma concentration of Clobazam.

Ritonavir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Clobazam

Pharmacodynamic effects

Possible increase of adverse effects.

Recommendations

Monitor closely for side effects.

A reduction in dosage may be necessary.

Alternative solution(s)

Gabapentin, pregabaline, leviracetam.

Monitor

Benzodiazepine toxicity: drowsiness, dizziness, ataxia, problem of coordination, confusion, decrease of reflexes, excessive sedation, respiratory depression and coma.

Tests

–

Pharmacokinetic parameters

–

Comment

–

Reference
  • 3309
    Clobazam (Teva-Clobazam), Teva, Ontario, Canada, 20 oct. 2017.