No pharmaceutical opinion available for this interaction.
Ritonavir can inhibit the metabolism (CYP 3A4) and increase the plasma concentration of Clobazam.
3A4 (main) and 2D6 (to a lesser extend)
1A2 and UGT (moderate); 2B6, 2C9 and 2C19 (weak)
3A4 (potent) and 2D6 (weak) Transportors: P-gp, OATP1A2 and OATP1B1
3A4 (major), 2C19 and 2B6 (to a lesser extent), P-gp; N-desmethylclobazam widely metabolized by 2C19
Possible increase of adverse effects.
Monitor closely for side effects.
A reduction in dosage may be necessary.
Gabapentin, pregabaline, leviracetam.
Benzodiazepine toxicity: drowsiness, dizziness, ataxia, problem of coordination, confusion, decrease of reflexes, excessive sedation, respiratory depression and coma.