Ritonavir

Buspirone

Evaluate risk/benefit ratio.

No pharmaceutical opinion available for this interaction.

Mechanism

Ritonavir may possibly inhibit the metabolism (CYP 3A4) and consequently increase the plasma concentration of Buspirone.

Ritonavir

Pharmacodynamic effects

Recommendations

Alternative solution(s)

Buspirone

Pharmacodynamic effects

Increased risk of CNS toxicity.

Recommendations

Use with caution the lowest effective dose and adjust according to clinical response and tolerance.

Monitor closely for adverse effects.

Alternative solution(s)

Lorazepam (Ativan), temazepam (Restoril), oxazepam (Serax).

Monitor

Buspirone toxicity: impaired psychomotor performance, nausea, vomiting, dizziness, drowsiness, miosis, etc.

Tests

Pharmacokinetic parameters

Comment

Ref #2385 : Case report of a patient with similar symptoms to Parkinson when Buspirone 40mg am/30mg pm was added with a patient who was taking Indinavir/Ritonavir (400mg/400mg).

Reference
  • 2573
    Ritonavir (Norvir), Corporation AbbVie, Quebec, Canada, 25 septembre 2018.
  • 2385
    Clay PG, Adams MM. Pseudo-Parkinson disease secondary to ritonavir-buspirone interaction. Annals of Pharmacotherapy 2003;37:202-5.