https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=3114
No pharmaceutical opinion available for this interaction.
Ritonavir can inhibit the metabolism (CYP 3A4) and increase the plasma concentration of Buspirone.
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Increased risk of CNS toxicity.
Use with caution the lowest effective dose and adjust according to clinical response and tolerance.
Monitor closely for adverse effects.
Lorazepam (Ativan), temazepam (Restoril), oxazepam (Serax).
Buspirone toxicity: impaired psychomotor performance, nausea, vomiting, dizziness, drowsiness, miosis, etc.
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Ref #2385 : Case report of a patient with similar symptoms to Parkinson when Buspirone 40mg am/30mg pm was added with a patient who was taking Indinavir/Ritonavir (400mg/400mg).