https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=22262

Glecaprevir / Pibrentasvir

Rifabutin

Contraindicated.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Rifabutin at steady state may induce CYP 3A4 and P-gp and decrease the plasma concentration of Glecaprevir / Pibrentasvir.

Glecaprevir / Pibrentasvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Avoid association.

Alternative solution(s)

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Rifabutin

Pharmacodynamic effects

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Recommendations

–

Alternative solution(s)

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Monitor

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Tests

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Pharmacokinetic parameters

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Comment

See glecaprevir/pibrentasvir + rifampin.

Reference

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