https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=21413

Sofosbuvir / Velpatasvir

Calcium (antacid)

A spacing between the drugs is required.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Calcium (antacid) by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of velpatasvir .

Sofosbuvir / Velpatasvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Administer at least 4 hours before or after the antacid.

Monitor for clinical efficacy.

Alternative solution(s)

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Calcium (antacid)

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

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Monitor

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Tests

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Pharmacokinetic parameters

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Comment

See sofosbuvir/velpatasvir + aluminium/magnesium hydroxide.

Reference
  • 3250
    Sofosbuvir/Velpatasvir (Epclusa), Gilead Sciences, Ontario, Canada, 5 novembre 2020.