https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19912

Bictegravir

Antacids

Administration time adjustment is recommended.

No pharmaceutical opinion available for this interaction.

Mechanism

Cations by chelation may reduce the absorption of Bictegravir.

Bictegravir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

If bictegravir taken with food: it may be taken with antacids without spacing dose.

If bictegravir taken fasting: it must be taken ideally 2 hours before or 2 hours after taking antacids.

Monitor for clinical efficacy.

Alternative solution(s)

–

Antacids

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Monitor

–

Tests

Bictegravir plasma level

CD4+

Viral load HIV

Pharmacokinetic parameters

–

Comment

For more details, see bictegravir + aluminium/magnesium hydroxide and bictegravir + calcium (antacid).

Comment
Reference
  • 3392
    Bictegravir/emtricitabine/tenofovir alafenamide (BIKTARVY), Gilead Sciences, Ontario, Canada, 14 avril 2023.