https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19911
No pharmaceutical opinion available for this interaction.
Cations by chelation may reduce the absorption of Bictegravir.
Possible decrease of clinical efficacy.
If bictegravir taken with food: it may be taken with calcium without spacing dose.
If bictegravir taken fasting: it must be taken ideally 2 hours before or 2 hours after taking iron.
Monitor for clinical efficacy.
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Bictegravir plasma level
CD4+
Viral load HIV
Reference number |
---|
# patients |
HIV |
Dose |
Frequency |
AUC |
Cmax |
3467 | 3467 |
---|---|
14 | 14 |
- | - |
50 mg | 50 mg |
x 1 | x 1 |
- 63% | - 16% |
- 71% | - 25% |
3467 | 3467 |
---|---|
14 | 14 |
- | - |
324 mg * | 324 mg † |
x 1 * | x 1 † |
Ref #3467 : * Simultaneous administration with bictegravir, fasted.
† Simultaneous administration with bictegravir, fed.
Ref #3715 : In a study of 33 HIV-positive pregnant women receiving B/F/TAF, only one patient had bictegravir levels below the protein-adjusted 95% effective concentration. This patient took calcium and iron supplements during pregnancy. Despite everything, she had an undetectable viral load, like all the other patients, throughout the pregnancy.