https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19910
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19910
No pharmaceutical opinion available for this interaction.
Cations by chelation may reduce the absorption of Bictegravir.
Possible decrease of clinical efficacy.
If bictegravir taken with food : it may be taken with calcium without spacing dose.
If bictegravir taken fasting: it must be taken ideally 2 hours before or 2 hours after taking antacids.
Monitor for clinical efficacy.
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Bictegravir plasma level
CD4+
Viral load HIV
| Reference number |
|---|
| # patients |
| HIV |
| Dose |
| Frequency |
| AUC |
| Cmax |
| 3392 | 3392 |
|---|---|
| 14 | 14 |
| - | - |
| 50 mg | 50 mg |
| x 1 | x 1 |
| - 33% | + 3% |
| - 42% | - 10% |
| 3392 | 3392 |
|---|---|
| 14 | 14 |
| - | - |
| 1200 mg * | 1200 mg † |
| x 1 * | x 1 † |
Ref #3392 : * Simultaneous administration with bictegravir, fasted.
† Simultaneous administration with bictegravir, fed.