Bictegravir

Magnesium (hydroxide)

Administration time adjustment is recommended.

No pharmaceutical opinion available for this interaction.

Mechanism

Cations by chelation may reduce the absorption of Bictegravir.

Bictegravir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

If bictegravir taken with food: it may be taken with antacids without spacing dose.

If bictegravir taken fasting: it must be taken ideally 2 hours before or 2 hours after taking antacids.

Monitor for clinical efficacy.

Alternative solution(s)

Magnesium (hydroxide)

Pharmacodynamic effects

Recommendations

Alternative solution(s)

Monitor

Tests

CD4+

Viral load HIV

Pharmacokinetic parameters

Comment

See bictegravir + aluminium/magnesium hydroxide.

Reference
  • 3392
    Bictegravir/emtricitabine/tenofovir alafenamide (BIKTARVY), Gilead Sciences, Ontario, Canada, 10 juillet 2018.