https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19908
No pharmaceutical opinion available for this interaction.
Cations by chelation may reduce the absorption of Bictegravir.
Possible decrease of clinical efficacy.
If bictegravir taken with food: it may be taken with antacids without spacing dose.
If bictegravir taken fasting: it must be taken ideally 2 hours before or 2 hours after taking antacids.
Monitor for clinical efficacy.
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Bictegravir plasma level
CD4+
Viral load HIV
Reference number |
---|
# patients |
HIV |
Dose |
Frequency |
AUC |
Cmax |
3467 | 3467 | 3467 | 3467 |
---|---|---|---|
14 | 13 | 13 | 14 |
- | - | - | - |
50 mg | 50 mg | 50 mg | 50 mg |
x 1 | x 1 | x 1 | x 1 |
- 79% | - 13% | - 52% | - 47% |
- 80% | - 7% | - 58% | - 49% |
3467 | 3467 | 3467 | 3467 |
---|---|---|---|
14 | 13 | 13 | 14 |
- | - | - | - |
1600/1600 mg * | 1600/1600 mg † | 1600/1600 mg ° | 1600/1600 mg ‡ |
x 1 * | x 1 † | x 1 ° | x 1 ‡ |
Ref #3467 : * Simultaneous administration with bictegravir, fasted.
† Administered 2 h after bictegravir fasted.
° Administered 2 h before bictegravir fasted.
‡ Simultaneous administration with bictegravir with food.