https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19335
Document made available to the pharmacist to communicate a drug interaction to the doctor.
DOWNLOADSofosbuvir / Velpatasvir / Voxilaprevir can inhibit OATP1B1 and increase the plasma concentration of Pravastatin.
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Possible increase of adverse effects.
Increased risk of myopathy and rhabdomyolysis.
Use this combination with caution.
No more than 40 mg per day is recommended.
Monitor for adverse effects.
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Symptoms of toxicity associated with hypolipidemic agents : gastrointestinal effects, fatigue and muscular weaknesses, myalgias, muscular cramps, myopathies, rhabdomyolysis and myoglobinuria leading to renal insufficiency.
CK
Lipidic profile
Reference number |
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# patients |
HCV |
Dose |
Frequency |
AUC |
Cmax |
3379 |
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19 |
- |
400/100/200 mg |
QD |
3379 |
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19 |
- |
40 mg |
x 1 |
+ 116% (2.1x) |
+ 89% (1.9x) |
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