https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19330

Sofosbuvir / Velpatasvir / Voxilaprevir

Digoxin

Use with caution.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Sofosbuvir / Velpatasvir / Voxilaprevir can decrease the P-gp and increase the plasma concentration of Digoxin.

Sofosbuvir / Velpatasvir / Voxilaprevir

Pharmacodynamic effects

–

Recommendations

–

Alternative solution(s)

–

Digoxin

Pharmacodynamic effects

Possible increase of adverse effects.

Recommendations

Use this combination with caution.

Monitor for development of adverse effects and adjust dosage if necessary.

Alternative solution(s)

–

Monitor

Adverse effects of digoxin: Gastrointestinal effects (abdominal discomfort, nausea/vomiting, diarrhea, anorexia, dyspepsia), central nervous system effects, vision disorders, fatigue, headache, bradycardia and rhythm disorders.

ECG

Tests

Digoxinemia

Pharmacokinetic parameters

–

Comment

Ref #3379 : Coadministration with sofosbuvir/velpatasvir/voxilaprevir has not been studied. In 21 healthy subjects, concomitant administration of a single dose of digoxin 0.25 mg with velpatasvir 100 mg QD increased digoxin AUC and Cmax by 34% and 88%, respectively.

Reference
  • 3379
    Sofosbuvir/Velpatasvir/Voxilaprevir (VOSEVI), Gilead, Ontario, Canada, 28 janvier 2020.