https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19326

Sofosbuvir / Velpatasvir / Voxilaprevir

Lansoprazole

Potential interaction.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Lansoprazole by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of velpatasvir .

Sofosbuvir / Velpatasvir / Voxilaprevir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy.

Alternative solution(s)

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Lansoprazole

Pharmacodynamic effects

–

Recommendations

PPI doses should not exceed comparable to omeprazole 20 mg QD either dexlansoprazole 30 mg; esomeprazole 20 mg; lansoprazole 30 mg; pantoprazole 40 mg; rabeprazole 20 mg.

Alternative solution(s)

–

Monitor

–

Tests

–

Pharmacokinetic parameters

–

Comment

See sofosbuvir/velpatasvir/voxilaprevir + omeprazole.

Comment
Reference
  • 3379
    Sofosbuvir/Velpatasvir/Voxilaprevir (VOSEVI), Gilead, Ontario, Canada, 28 janvier 2020.