https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=19320

Sofosbuvir / Velpatasvir / Voxilaprevir

Nizatidine

Administration time adjustment is recommended.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Nizatidine by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of velpatasvir .

Sofosbuvir / Velpatasvir / Voxilaprevir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy.

Alternative solution(s)

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Nizatidine

Pharmacodynamic effects

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Recommendations

Administrer at the same time and/or 12 hours after the combined drug.

Recommended dosage : dose not exceeding famotidine 40 mg twice daily or equivalent.

Alternative solution(s)

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Monitor

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Tests

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Pharmacokinetic parameters

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Comment

See sofosbuvir/velpatasvir/voxilaprevir + famotidine.

Reference
  • 3379
    Sofosbuvir/Velpatasvir/Voxilaprevir (VOSEVI), Gilead, Ontario, Canada, 28 janvier 2020.