Sofosbuvir / Velpatasvir / Voxilaprevir

Aluminium / Magnesium hydroxide

A spacing between the drugs is required.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Aluminium / Magnesium hydroxide by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of velpatasvir .

Sofosbuvir / Velpatasvir / Voxilaprevir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Administer at least 4 hours before or after the antacid.

Monitor for clinical efficacy.

Alternative solution(s)

Aluminium / Magnesium hydroxide

Pharmacodynamic effects

Recommendations

Alternative solution(s)

Monitor

Tests

Pharmacokinetic parameters

Comment

Reference
  • 3379
    Sofosbuvir/Velpatasvir/Voxilaprevir (VOSEVI), Gilead, Ontario, Canada, 18 avril 2018.