https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=18399

Cobicistat

Codeine

Dosage adjustment may be necessary.

No pharmaceutical opinion available for this interaction.

Mechanism

Cobicistat may inhibit the metabolism (CYP2D6) and decrease the conversion into morphine, active metabolite of Codeine.

Cobicistat

Pharmacodynamic effects

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Recommendations

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Alternative solution(s)

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Codeine

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy and adjust the dosage if necessary.

Alternative solution(s)

Hydromorphone or morphine.

Monitor

Signs and symptoms of opioid withdrawal : craving for opioids, irritability, myalgias, muscle spasms, flushing, abdominal pain, nausea, vomiting, diarrhea, restlessness, diaphoresis, lacrimation, rhinorrhea, mydriasis, yawning, piloerection (goose flesh), tachycardia, tremulousness.

Tests

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Pharmacokinetic parameters

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Comment

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Reference

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