https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=18398
No pharmaceutical opinion available for this interaction.
Atazanavir / cobicistat may inhibit the metabolism (CYP2D6) and decrease the conversion into morphine, active metabolite of Codeine.
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Possible decrease of clinical efficacy.
Monitor for clinical efficacy and adjust the dosage if necessary.
Depending on the clinical indication, acetaminophen, NSAIDs when possible, hydromorphone or morphine.
Signs and symptoms of opioid withdrawal : craving for opioids, irritability, myalgias, muscle spasms, flushing, abdominal pain, nausea, vomiting, diarrhea, restlessness, diaphoresis, lacrimation, rhinorrhea, mydriasis, yawning, piloerection (goose flesh), tachycardia, tremulousness.
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