https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=18061
https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=18061
No pharmaceutical opinion available for this interaction.
Darunavir / cobicistat can inhibit the metabolism (CYP 3A4) and increase the plasma concentration of Nitrazepam.
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Increased risk of CNS toxicity.
Risk of prolonged sedation and respiratory depression.
Use with caution the lowest effective dose and adjust according to clinical response and tolerance.
Monitor closely for adverse effects.
Or choose an alternative.
In patients already being treated with this combination and tolerating it, if deemed appropriate, keep actual treatment and exercise close monitoring of adverse effects.
Lorazepam (Ativan), temazepam (Restoril), oxazepam (Serax)
Benzodiazepine toxicity: drowsiness, dizziness, ataxia, problem of coordination, confusion, decrease of reflexes, excessive sedation, respiratory depression and coma.
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