https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=16417

Sofosbuvir / Velpatasvir

Simvastatin

Dosage adjustment may be necessary.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Sofosbuvir / Velpatasvir can inhibit BCRP and increase the plasma concentration of Simvastatin.

Sofosbuvir / Velpatasvir

Pharmacodynamic effects

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Recommendations

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Alternative solution(s)

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Simvastatin

Pharmacodynamic effects

Possible increase of adverse effects.

Recommendations

Use this combination with caution.

Use the lowest effective dose and titrate according to clinical response and occurrence of adverse effects.

Monitor closely.

Alternative solution(s)

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Monitor

Symptoms of toxicity associated with hypolipidemic agents : gastrointestinal effects, fatigue and muscular weaknesses, myalgias, muscular cramps, myopathies, rhabdomyolysis and myoglobinuria leading to renal insufficiency.

Tests

CK

Lipidic profile

Pharmacokinetic parameters

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Comment

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Reference

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