Sofosbuvir / Velpatasvir

Lovastatin

Dosage adjustment may be necessary.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Sofosbuvir / Velpatasvir can inhibit OATP1B1 and increase the plasma concentration of Lovastatin.

Sofosbuvir / Velpatasvir

Pharmacodynamic effects

Recommendations

Alternative solution(s)

Lovastatin

Pharmacodynamic effects

Possible increase of adverse effects.

Recommendations

Use this combination with caution.

Use the lowest effective dose and titrate according to clinical response and occurrence of adverse effects.

Monitor closely.

Alternative solution(s)

Monitor

Symptoms of toxicity associated with hypolipidemic agents : gastrointestinal effects, fatigue and muscular weaknesses, myalgias, muscular cramps, myopathies, rhabdomyolysis and myoglobinuria leading to renal insufficiency.

Tests

CK

Lipidic profile

Pharmacokinetic parameters

Comment

Reference
  • 2678
    Losartan (Cozaar), Merck, Québec, Canada, 17 septembre 2018.