https://interactions.guidetherapeutiquevih.com/en/interaction-details?id=16255

Sofosbuvir / Velpatasvir

St. John's Wort

Combination not recommended.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

St. John's Wort may induce CYP 3A4 and P-gp and decrease the plasma concentration of Sofosbuvir / Velpatasvir.

Sofosbuvir / Velpatasvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Do not administer with potent P-gp inducers or with moderate to potent CYP2B6, 2C8 or 3A4 inducers.

Alternative solution(s)

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St. John's Wort

Pharmacodynamic effects

–

Recommendations

Association not recommended.

Alternative solution(s)

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Monitor

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Tests

–

Pharmacokinetic parameters

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Comment

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Comment
Reference
  • 3250
    Sofosbuvir/Velpatasvir (Epclusa), Gilead Sciences, Ontario, Canada, 5 novembre 2020.