Sofosbuvir / Velpatasvir

Lansoprazole

Modification of dose and/or administration time necessary.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

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Mechanism

Lansoprazole by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of velpatasvir .

Sofosbuvir / Velpatasvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy.

Alternative solution(s)

Lansoprazole

Pharmacodynamic effects

Recommendations

Proton-pump inhibitor can be administered simultaneously with ledipasvir/sofosbuvir when it is taken with food.

PPI doses should not exceed comparable to omeprazole 20 mg QD either dexlansoprazole 30 mg; esomeprazole 20 mg; lansoprazole 30 mg; pantoprazole 40 mg; rabeprazole 20 mg.

Alternative solution(s)

Monitor

Tests

Pharmacokinetic parameters

Comment

See sofosbuvir/velpatasvir + omeprazole.

Reference
  • 3250
    Sofosbuvir/Velpatasvir (Epclusa), Gilead Sciences, Ontario, Canada, 16 avril 2018.