Sofosbuvir / Velpatasvir

Cimetidine

Administration time adjustment is recommended.

Available pharmaceutical opinion

Document made available to the pharmacist to communicate a drug interaction to the doctor.

DOWNLOAD
Mechanism

Cimetidine by increasing gastric pH may decrease the solubility, absorption, and plasma concentration of velpatasvir .

Sofosbuvir / Velpatasvir

Pharmacodynamic effects

Possible decrease of clinical efficacy.

Recommendations

Monitor for clinical efficacy.

Alternative solution(s)

Cimetidine

Pharmacodynamic effects

Recommendations

Administrer at the same time and/or 12 hours after the combined drug.

Recommended dosage : dose not exceeding famotidine 40 mg twice daily or equivalent.

Alternative solution(s)

Monitor

Tests

Pharmacokinetic parameters

Comment

See sofosbuvir/velpatasvir + famotidine.

Reference
  • 3250
    Sofosbuvir/Velpatasvir (Epclusa), Gilead Sciences, Ontario, Canada, 16 avril 2018.